An international team of researchers has developed a drug delivery technique that utilizes Graphene strips as “flying carpets” to deliver two anticancer drugs sequentially to cancer cells, with each drug targeting the distinct part of the cell where it will be most effective. The technique was found to perform better than either drug in isolation when tested in a mouse model targeting a human lung cancer tumor.
GRAPHENE has successfully proved itself in the lab against six kinds of cancer cells. Flaked Graphene oxide preferentially hits these cancers right in the stem cells. These are the guys that not only are often responsible for starting the tumor, but they also tend to stick around after the radiation, chemotherapy, and surgery to reseed a tumor just when it looks like it was defeated.
Jerry Neil Paul, a Founding Board Member of the Mesothelioma Research Foundation of America, has an objective to bring encouragement to cancer patients who are victims of mesothelioma. This recent cancer cure research from North Carolina State University , and the University of North Carolina at Chapel Hill, as well as the China Pharmaceutical University have also found a protein, TRAIL, that is anti-cancerous. This protein can be used to serve as an active targeting molecule that binds directly to a cancer cell.
Current research studies using Graphene strips show that anti-cancer drugs can be attached to the Graphene for focused delivery to the cancer cell. Graphene is particularly useful for this because it is a two-dimensional sheet of carbon only one atom in thickness. While the Mesothelioma Research Foundation of America has developed Veglin and EphB4, and others have developed TRAIL and Doxorubiein (Dox), non-chemotherapy drug treatments, all the treatments could be conducive to a Graphene strip delivery method. The Graphene delivery method is useful when the oncologist wants an effective sequential application of two drugs that work together, where each drug kills the cancer cell where it will be most effective. Some drug treat ments attach to the external membrane of the cancer cell to kill it, while other drug treatments effectively kill the cancer cell when delivered to the cell nucleus.
The Graphene strip works when a cancer drug treatment can be physically integrated and bound to it because of similar molecular structures of Graphene and the drug. So, various drug treatments can be attached to the surface of the Graphene by a combination of amino acids known as peptides.
Dr. Parkish Gill, on behalf of the Mesothelioma Research Foundation of America will determine if there is a way to apply and proceed with his non-chemotherapy treatments using the Graphene strip technique.
The paper, “Furin-Mediated Sequential Delivery of Anticancer Cytokine and Small-Molecule Drug Shuttled by Graphene,” was published in early view online Dec. 15 in Advanced Materials. Lead author of the paper is Dr. Tianyue Jiang, a former graduate student lab-researcher on the study who is now on faculty at Nanjing Tech University . The co-corresponding author is Dr. Ran Mo, who is also a former postdoctoral lab-researcher on this project who is now on faculty at CPU. Co-authors include Wujin Sun, a Ph.D. student in the lab of this project; Qiuwen Zhu, a Ph.D. student at CPU; Nancy Burns, a Ph.D. student at NC State; and Dr. Saad Khan, Alcoa Professor of Chemical and Biomolecular Engineering at NC State.
The Mesothelioma Research Foundation of America has a mission: fund research that will lead to the quickest cure for mesothelioma. Mesothelioma is a cancer of the lining of the lungs caused by asbestos exposure. This cancer disease had few treatment options until this Foundation and Dr. Parkash Gill's work created better treatment options. Today, the future looks more hopeful for additional improved treatment options available to those stricken by this cancer.
The Mesothelioma Research Foundation of America began funding research for a cure in 2001 with the opening of the Mesothelioma Laboratory at USC Norris Comprehensive Cancer Medical Center in Los Angeles under the supervision of Dr. Parkash Gill.
Dr. Gill is a board certified oncologist and hematologist who has received FDA approval from the U.S. Government to do Clinical Trials on a mesothelioma treatment drug called Veglin. We believe there is great promise and hope in Veglin and the Mesothelioma Research Foundation of America has funded 100% of Dr. Gill's research.
Veglin proved successful in Phase I and Phase II clinical trials. Many are very hopeful for the possibilities of a more effective cancer treatment compared to what presently is available for mesothelioma victims. We are currently in FDA approved Clinical Trials with EPH-B4 which replaced the Veglin Trials.
By Robert Buscemi
The United Association Southern California Pipe Trades Council 16 presented the Mesothelioma Research Foundation of America with a check for $200,000 at the Council's annual holiday lunch.
The money, all raised in 2014, will go toward a cure for mesothelioma, a cancer caused by exposure to asbestos. District Council 16 Director of Organizing John Ferruccio emceed the event December 12 at the Dodger Stadium Club. He held off announcing the impressive dollar figure until after the speeches, when a drum roll from the house band built the excitement.
“Every year, as you know, one of our main fundraisers is to find a cure for this unfortunate disease,” Ferruccio told more than 150 attendees. “Mostly, mesothelioma is affecting our grandfathers, fathers and fathers-in-law. It's gotten a lot better over the years.”
Ferruccio said the Council hosts an annual golf tournament and skeet-shooting events. In addition, the State Building and Construction Trade Council of California raises money through the annual Roger Hamilton golf invitational.
The foundation, known as MESORFA, was founded in 2001 by attorney Jerry Neil Paul, his wife Elizabeth Ann Paul and retired California Pipe Trades Representative and past Vice President of the State Building and Construction Trade Council, Jim Kellogg.
In thanking District Council 16, MESORFA Executive Director Elizabeth Paul explained that all funding goes toward research rather than administration. “All of this money goes directly to fund a lab at USC Norris Comprehensive Cancer Center here in Los Angeles . We use 100 percent of every dollar donated toward research, for clinical trials and to fund the lab. Nothing goes for the foundation – those costs are privately underwritten.”
Paul said such research is never cheap, and other cancers get more attention and funding than mesothelioma, especially in a tight economy. Indeed, she said, MESORFA operates on a shoestring budget. “I know people don't understand that, but to bring a treatment to the public costs tens of millions of dollars.”
As such, Paul said District Council 16's annual contribution is crucial. “Everybody was extremely generous. Families took care of families. My husband Jerry and I are big on family. Your leaders at District Council 16 view your members as family. Because they have gone out of their way to make sure that there are treatments and cures for this horrible disease.”
The disease hits especially hard at workers who have been exposed to asbestos, as many Pipe Trades and other Building Trades were before protections were put in place against the toxic substance. Even now, workers confront the hazard at some job sites.
Paul then introduced Dr. Parkash Gill, who reported that he has made huge strides at his lab through the development of Veglin, a drug that treats the disease. “I'm honored to be part of it,” Gill said. “It's a worthy cause. I'm a cancer doctor, so finding a treatment for patients really is a rewarding experience. When somebody is ill and they get better and they go home and never see you again, it's wonderful.”
Gill said that patients are already seeing positive results at treatment advances. He said certain efforts have been completely successful. “This medicine, we have given to a 78-year-old patient. Two or three years out now, there's no cancer left and no side effects.”
Dr. Parkash Gill of the USC Norris Comprehensive Cancer Center has announced that the new cancer fighting drug EPH-B4 has been submitted to the FDA for Phase I Clinical Trials and is available to qualifying mesothelioma patients. In the initial Phase I Trial EPH-B4 is available to newly diagnosed patients who have not undergone any conventional treatment options and to those patients who have exhausted all other treatment options such as surgery and chemotherapy. This is truly exciting as Dr. Gill has reported that EPH-B4 has shown great promise as a solo treatment or in conjunction with other drugs as Alimta, Cisplatin and Carboplatin.
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There have been significant improvements creating new options for patients with Mesothelioma lung cancer. This video presents the new options for a patient to be aware of and consider. This news release video, created by Med Page Today, is about Oncology and Lung Cancer has been shared on YouTube by the Mesothelioma Research Foundation of America.
The Mesothelioma Research Foundation of America is the proud recipient of a grant from the John S. Lyons Memorial Foundation, charitable branch of the San Diego Building Trades Councel, to help support clinical studies of Dr. Parkash Gill's protein known as EPH B4 as a mesothelioma cancer treatment option.
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